James Phelan

2 months ago | mondaq.com | Vincent Coyne |James Phelan

In this month's edition we look at:Dates & Deadlines: Q1 2025 / Q2 2025Stay ahead of upcoming deadlines and key dates with our legal& regulatory tracker. Compliance and Internal audit Functions- ESMA CommonSupervisory ActionOn 17 February, the Central Bank of Ireland(CBI) circulated a questionnaire on the complianceand internal audit functions of UCITS management companies andAIFMs to a sample group of fund management companies forcompletion.

2 months ago | lexology.com | Vincent Coyne |James Phelan

In this month’s edition we look at: Dates & Deadlines: Q1 2025 / Q2 2025 Stay ahead of upcoming deadlines and key dates with our legal & regulatory tracker. Compliance and Internal audit Functions- ESMA Common Supervisory Action On 17 February, the Central Bank of Ireland (CBI) circulated a questionnaire on the compliance and internal audit functions of UCITS management companies and AIFMs to a sample group of fund management companies for completion.

2 months ago | lexology.com | Vincent Coyne |James Phelan

In this month’s edition we look at: Dates & Deadlines: Q1 2025 / Q2 2025 Stay ahead of upcoming deadlines and key dates with our legal & regulatory tracker. DORA Update – Financial Services with an ICT Component From 17 January 2025, financial entities subject to the Digital Operational Resilience Act (DORA) are obliged to submit reports on major information and communication technology (ICT)-related incidents to the CBI.

Jul 18, 2024 | nature.com | Maryam Yamadi |James Phelan |Michael Kelly |Ryan Young |Stefania Pittaluga |Sriranjani Darbha | +1 more

AbstractGerminal centers (GCs) that form in mucosal sites are exposed to gut-derived factors that have the potential to influence homeostasis independent of antigen receptor-driven selective processes. The G-protein Gα13 confines B cells to the GC and limits the development of GC-derived lymphoma. We discovered that Gα13-deficiency fuels the GC reaction via increased mTORC1 signaling and Myc protein expression specifically in the mesenteric lymph node (mLN).