Sriranjani Darbha

Jul 18, 2024 | nature.com | Maryam Yamadi |James Phelan |Michael Kelly |Ryan Young |Stefania Pittaluga |Sriranjani Darbha | +1 more

AbstractGerminal centers (GCs) that form in mucosal sites are exposed to gut-derived factors that have the potential to influence homeostasis independent of antigen receptor-driven selective processes. The G-protein Gα13 confines B cells to the GC and limits the development of GC-derived lymphoma. We discovered that Gα13-deficiency fuels the GC reaction via increased mTORC1 signaling and Myc protein expression specifically in the mesenteric lymph node (mLN).