Jamie K. Moon

Nov 19, 2024 | science.org | Eyal Zoler |Matthew Knarr |Leslie K. Ferrarelli |Jamie K. Moon

Editor’s summaryHigh-grade serous ovarian cancer (HGSOC) is aggressive and lacks durably effective treatments. Forskolin can suppress cancer cell proliferation but cannot be used clinically. Knarr et al. found that colforsin daropate, a forskolin derivative, specifically induced cell death in HGSOC cells but not normal fallopian or ovarian cells and inhibited HGSOC invasion in part by attenuating MYC signaling.