Matthew Knarr

Nov 19, 2024 | science.org | Eyal Zoler |Matthew Knarr |Leslie K. Ferrarelli |Jamie K. Moon

Editor’s summaryHigh-grade serous ovarian cancer (HGSOC) is aggressive and lacks durably effective treatments. Forskolin can suppress cancer cell proliferation but cannot be used clinically. Knarr et al. found that colforsin daropate, a forskolin derivative, specifically induced cell death in HGSOC cells but not normal fallopian or ovarian cells and inhibited HGSOC invasion in part by attenuating MYC signaling.

Nov 19, 2024 | science.org | Eyal Zoler |Matthew Knarr |Leslie K. Ferrarelli |Thomas Meyer

Editor’s summaryType I interferons (IFNs) stimulate antiviral or antiproliferative signaling in a cell type–dependent manner. The Janus kinases TYK2 and JAK1 are recruited to the IFN receptor subunits IFNAR1 and IFNAR2, respectively, cross-phosphorylating each other and STAT proteins to transduce IFN signals. However, in experiments with synthetic IFNARs and JAK-deficient cell lines, Zoler et al.

Nov 19, 2024 | science.org | Eyal Zoler |Matthew Knarr |Leslie K. Ferrarelli

AbstractThe kinase TYK2 facilitates pathological tau assembly through protein-stabilizing modifications. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Tauopathies are a diverse group of neurodegenerative diseases caused by the abnormal self-assembly of tau, a protein that promotes cellular function by stabilizing microtubules, the filaments that support cell shape and movement.