Jan Eric Kolberg

Aug 15, 2023 | biorxiv.org | Martin J. Mueller |Alexandra Herrmann |Shigeru Fujita |Jan Eric Kolberg

AbstractSARS-CoV-2 proteins are translated from subgenomic RNAs (sgRNAs). While most of these sgRNAs are monocistronic, some viral mRNAs encode more than one protein. For example, the ORF3a sgRNA also encodes ORF3c, an enigmatic 41-amino acid peptide. Here, we show that ORF3c is expressed in SARS-CoV-2 infected cells and suppresses RIG-I- and MDA5-mediated immune activation and IFN-β induction.