Ján Remšík

Nov 15, 2024 | cell.com | Ján Remšík |KU Leuven |Adrienne Boire

Get full text accessLog in, subscribe or purchase for full access. References1. Long, G.V. ∙ Atkinson, V. ∙ Lo, S. ... Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 studyLancet Oncol. 2018; 19:672-6812. Tawbi, H.A. ∙ Forsyth, P.A. ∙ Algazi, A. ... Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the BrainN. Engl. J. Med. 2018; 379:722-7303. Wang, C. ∙ Zeng, Q. ∙ Gul, Z.M. ...

Jun 13, 2024 | nature.com | Ján Remšík |Adrienne Boire

AbstractThe leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous system, play host to various pathologies including infection, neuroinflammation and malignancy. Spread of systemic cancer into this space, termed leptomeningeal metastasis, occurs in 5–10% of patients with solid tumours and portends a bleak clinical prognosis. Previous, predominantly descriptive, clinical studies have provided few insights.