Jared Johnson

Sep 27, 2024 | nature.com | Yuqin Wu |Susanne Hille |Jared Johnson |Cheng Huang |Mohammad Rahbari |Suchira Gallage | +7 more

AbstractThe peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic metabolic actions. Given that the liver is a chief site of action, we performed in situ time-resolved liver phosphoproteomics to reveal glucagon signaling nodes.

May 28, 2024 | science.org | Lavinia Palamiuc |Emilio Hirsch |Leslie K. Ferrarelli |Jared Johnson

Research ArticleCELL BIOLOGYLavinia Palamiuc https://orcid.org/0009-0000-1074-997X, Jared L. Johnson https://orcid.org/0000-0003-1802-6527, [...] , Zeinab Haratipour https://orcid.org/0000-0003-4577-204X, Ryan M. Loughran https://orcid.org/0000-0002-6384-1662, [...] , Woong Jae Choi https://orcid.org/0000-0002-7967-3501, Gurpreet K.

Feb 23, 2023 | nature.com | Hyuk-Soo Seo |Jared Johnson |Jianwei Che |Lewis C. Cantley |Benjamin Cravatt |Sirano Dhe-Paganon | +2 more

AbstractCreatine kinases (CKs) provide local ATP production in periods of elevated energetic demand, such as during rapid anabolism and growth. Thus, creatine energetics has emerged as a major metabolic liability in many rapidly proliferating cancers. Whether CKs can be targeted therapeutically is unknown because no potent or selective CK inhibitors have been developed.