Susanne Hille

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Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon - Nature Communications

Sep 27, 2024 | nature.com | Yuqin Wu |Susanne Hille |Jared Johnson |Cheng Huang |Mohammad Rahbari |Suchira Gallage | +7 more

AbstractThe peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic metabolic actions. Given that the liver is a chief site of action, we performed in situ time-resolved liver phosphoproteomics to reveal glucagon signaling nodes.

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