Jared Zhang

Jul 20, 2024 | biorxiv.org | Milankumar Prajapati |Jared Zhang |Grace Chong |Lauren Chiu

AbstractSLC30A10 deficiency is a disease of severe manganese excess attributed to loss of SLC30A10-dependent manganese excretion via the gastrointestinal tract. Patients develop dystonia, cirrhosis, and polycythemia. They are treated with chelators but also respond to oral iron, suggesting that iron can outcompete manganese for absorption in this disease. Here we explore the latter observation. Intriguingly, manganese absorption is increased in Slc30a10-deficient mice despite manganese excess.

Apr 23, 2024 | insight.jci.org | JCI Insight |Milankumar Prajapati |Jared Zhang |Lauren Chiu

ResearchGeneticsHepatologyOpen Access | 10.1172/jci.insight.169738 JCI Insight. https://doi.org/10.1172/jci.insight.169738. Copyright © 2024, Prajapati et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF AbstractManganese is an essential yet potentially toxic metal.