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1 month ago | 
insight.jci.org | JCI Insight |Mohammed Asker |Jean-Philippe Krieger |Ivana Maric
AbstractOxytocin plays a key role in reproductive physiology but has recently garnered interest for its involvement in modulating feeding behavior. The vagus nerve contributes to feeding behavior control, as well as other gastrointestinal functions. Oxytocin receptors (OTR) are expressed on the vagus, but their role is poorly understood. Herein, we evaluated the contribution of the vagal OTR to food intake and body weight control in male and female rats.
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2 months ago | 
insight.jci.org | JCI Insight |Chen Kang |Litao Xie |John Tranter
ResearchCell biologyMetabolismOpen Access | 10.1172/jci.insight.188020 JCI Insight. https://doi.org/10.1172/jci.insight.188020. Copyright © 2025, Abd El-Aziz et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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2 months ago | 
insight.jci.org | JCI Insight |Julie D. Pourtois |Naomi L. Haddock |Aditi Gupta
ResearchInfectious diseaseMicrobiologyOpen Access | 10.1172/jci.insight.188146 JCI Insight. https://doi.org/10.1172/jci.insight.188146. Copyright © 2025, Pourtois et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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2 months ago | 
insight.jci.org | JCI Insight |Deanna N. Edwards |Shan Wang |Kelby M Kane
ResearchImmunologyMetabolismOncologyOpen Access | 10.1172/jci.insight.187531 JCI Insight. https://doi.org/10.1172/jci.insight.187531. Copyright © 2025, Edwards et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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2 months ago | 
insight.jci.org | JCI Insight |Sarah Glass |Matthew Bechard |Zheng Cao
ResearchCell biologyOncologyOpen Access | 10.1172/jci.insight.186938 JCI Insight. https://doi.org/10.1172/jci.insight.186938. Copyright © 2025, Glass et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Mar 11, 2025 | 
insight.jci.org | JCI Insight |Zhicheng Hu |Meghshree Deshmukh |Anders Jarneborn
ResearchBone biologyInfectious diseaseOpen Access | 10.1172/jci.insight.184954 JCI Insight. https://doi.org/10.1172/jci.insight.184954. Copyright © 2025, Hu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Mar 10, 2025 | 
insight.jci.org | JCI Insight |Bryce Jones |Debora L Gisch |Komuraiah Myakala
AbstractChronic kidney disease (CKD) is associated with renal metabolic disturbances, including impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small molecule that participates in hundreds of metabolism-related reactions. NAD+ levels are decreased in CKD, and NAD+ supplementation is protective. However, both the mechanism of how NAD+ supplementation protects from CKD, as well as the cell types involved, are poorly understood.
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Feb 24, 2025 | 
insight.jci.org | JCI Insight |Stephanie Le |Alexander A. Merleev |Alina I. Marusina
AbstractNecrobiosis is a histologic term used to describe abnormal deposits of “degenerating” collagen within the skin. It can be found as an incidental finding in various granulomatous conditions, but is a hallmark of necrobiosis lipoidica (NL) and necrobiotic xanthogranuloma (NXG). There is limited prior research on necrobiosis. Here, we employed single-cell analysis of lesional and nonlesional skin to study the pathophysiology of necrobiosis.
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Feb 18, 2025 | 
insight.jci.org | JCI Insight |Andres R. Valdivia |Andrés Reyes Valdivia |Horacio Cardenas |Horacio Cárdenas |Ana Isac
ResearchCell biologyOncologyOpen Access | 10.1172/jci.insight.184935 JCI Insight. https://doi.org/10.1172/jci.insight.184935. Copyright © 2025, Valdivia et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF AbstractThe omentum is the primary site of metastasis for ovarian cancer (OC).
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Jan 28, 2025 | 
insight.jci.org | JCI Insight |Aniket Joshi |Ashok Kumar
ResearchCell biologyMuscle biologyStem cellsOpen Access | 10.1172/jci.insight.187825 JCI Insight. https://doi.org/10.1172/jci.insight.187825. Copyright © 2025, Tomaz da Silva et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF AbstractSkeletal muscle regeneration in adults is predominantly driven by satellite cells.
