-
2 weeks ago | 
insight.jci.org | JCI Insight |Chen Kang |Litao Xie |John Tranter
ResearchCell biologyMetabolismOpen Access | 10.1172/jci.insight.188020 JCI Insight. https://doi.org/10.1172/jci.insight.188020. Copyright © 2025, Abd El-Aziz et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
-
3 weeks ago | 
insight.jci.org | JCI Insight |Julie D. Pourtois |Naomi L. Haddock |Aditi Gupta
ResearchInfectious diseaseMicrobiologyOpen Access | 10.1172/jci.insight.188146 JCI Insight. https://doi.org/10.1172/jci.insight.188146. Copyright © 2025, Pourtois et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
-
1 month ago | 
insight.jci.org | JCI Insight |Deanna N. Edwards |Shan Wang |Kelby M Kane
ResearchImmunologyMetabolismOncologyOpen Access | 10.1172/jci.insight.187531 JCI Insight. https://doi.org/10.1172/jci.insight.187531. Copyright © 2025, Edwards et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
-
1 month ago | 
insight.jci.org | JCI Insight |Sarah Glass |Matthew Bechard |Zheng Cao
ResearchCell biologyOncologyOpen Access | 10.1172/jci.insight.186938 JCI Insight. https://doi.org/10.1172/jci.insight.186938. Copyright © 2025, Glass et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
-
2 months ago | 
insight.jci.org | JCI Insight |Zhicheng Hu |Meghshree Deshmukh |Anders Jarneborn
ResearchBone biologyInfectious diseaseOpen Access | 10.1172/jci.insight.184954 JCI Insight. https://doi.org/10.1172/jci.insight.184954. Copyright © 2025, Hu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
-
2 months ago | 
insight.jci.org | JCI Insight |Bryce Jones |Debora L Gisch |Komuraiah Myakala
AbstractChronic kidney disease (CKD) is associated with renal metabolic disturbances, including impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small molecule that participates in hundreds of metabolism-related reactions. NAD+ levels are decreased in CKD, and NAD+ supplementation is protective. However, both the mechanism of how NAD+ supplementation protects from CKD, as well as the cell types involved, are poorly understood.
-
Jan 28, 2025 | 
insight.jci.org | JCI Insight |Aniket Joshi |Ashok Kumar
ResearchCell biologyMuscle biologyStem cellsOpen Access | 10.1172/jci.insight.187825 JCI Insight. https://doi.org/10.1172/jci.insight.187825. Copyright © 2025, Tomaz da Silva et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF AbstractSkeletal muscle regeneration in adults is predominantly driven by satellite cells.
-
Jan 23, 2025 | 
insight.jci.org | JCI Insight |Sudarshan Bhattacharjee |Jianing Gao |Yao Lu
AbstractDiabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying the regulation of vascular endothelial growth factor–dependent (VEGF-dependent) angiogenesis remain unclear. In our study, the molecular underpinnings of endothelial dysfunction in diabetes are investigated, focusing on the roles of disabled-2 (Dab2) and Forkhead box M1 (FOXM1) in VEGF receptor 2 (VEGFR2) signaling and endothelial cell function.
-
Jan 9, 2025 | 
insight.jci.org | JCI Insight |Bo Wang |Yun Xia |Can Zhou
AbstractCD4+ T cells contribute to antitumor immunity and are implicated in the efficacy of cancer immunotherapies. In particular, CD4+ T helper 2 (Th2) cells were recently found to block spontaneous breast carcinogenesis. However, the antitumor potential of Th2 cells in targeting established breast cancer remains uncertain.
-
Dec 10, 2024 | 
insight.jci.org | JCI Insight |Shanna L. Hosking |Lachlan M. Moldenhauer |Ha Tran
ResearchImmunologyReproductive biologyOpen Access | 10.1172/jci.insight.169836 JCI Insight. https://doi.org/10.1172/jci.insight.169836. Copyright © 2024, Hosking et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
