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2 weeks ago | 
insight.jci.org | JCI Insight |Deanna N. Edwards |Shan Wang |Kelby M Kane
ResearchImmunologyMetabolismOncologyOpen Access | 10.1172/jci.insight.187531 JCI Insight. https://doi.org/10.1172/jci.insight.187531. Copyright © 2025, Edwards et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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3 weeks ago | 
insight.jci.org | JCI Insight |Sarah Glass |Matthew Bechard |Zheng Cao
ResearchCell biologyOncologyOpen Access | 10.1172/jci.insight.186938 JCI Insight. https://doi.org/10.1172/jci.insight.186938. Copyright © 2025, Glass et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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1 month ago | 
insight.jci.org | JCI Insight |Zhicheng Hu |Meghshree Deshmukh |Anders Jarneborn
ResearchBone biologyInfectious diseaseOpen Access | 10.1172/jci.insight.184954 JCI Insight. https://doi.org/10.1172/jci.insight.184954. Copyright © 2025, Hu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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1 month ago | 
insight.jci.org | JCI Insight |Bryce Jones |Debora L Gisch |Komuraiah Myakala
AbstractChronic kidney disease (CKD) is associated with renal metabolic disturbances, including impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small molecule that participates in hundreds of metabolism-related reactions. NAD+ levels are decreased in CKD, and NAD+ supplementation is protective. However, both the mechanism of how NAD+ supplementation protects from CKD, as well as the cell types involved, are poorly understood.
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2 months ago | 
insight.jci.org | JCI Insight |Aniket Joshi |Ashok Kumar
ResearchCell biologyMuscle biologyStem cellsOpen Access | 10.1172/jci.insight.187825 JCI Insight. https://doi.org/10.1172/jci.insight.187825. Copyright © 2025, Tomaz da Silva et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF AbstractSkeletal muscle regeneration in adults is predominantly driven by satellite cells.
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Jan 23, 2025 | 
insight.jci.org | JCI Insight |Sudarshan Bhattacharjee |Jianing Gao |Yao Lu
AbstractDiabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying the regulation of vascular endothelial growth factor–dependent (VEGF-dependent) angiogenesis remain unclear. In our study, the molecular underpinnings of endothelial dysfunction in diabetes are investigated, focusing on the roles of disabled-2 (Dab2) and Forkhead box M1 (FOXM1) in VEGF receptor 2 (VEGFR2) signaling and endothelial cell function.
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Jan 9, 2025 | 
insight.jci.org | JCI Insight |Bo Wang |Yun Xia |Can Zhou
AbstractCD4+ T cells contribute to antitumor immunity and are implicated in the efficacy of cancer immunotherapies. In particular, CD4+ T helper 2 (Th2) cells were recently found to block spontaneous breast carcinogenesis. However, the antitumor potential of Th2 cells in targeting established breast cancer remains uncertain.
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Dec 10, 2024 | 
insight.jci.org | JCI Insight |Shanna L. Hosking |Lachlan M. Moldenhauer |Ha Tran
ResearchImmunologyReproductive biologyOpen Access | 10.1172/jci.insight.169836 JCI Insight. https://doi.org/10.1172/jci.insight.169836. Copyright © 2024, Hosking et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Dec 6, 2024 | 
insight.jci.org | JCI Insight |Fuxiang Li |Chuanzhi Zhu |Yue Zhang
AbstractIntroductionPleural effusions (PEs) present a substantial clinical challenge, arising from over 50 identified causes, including local pleural or pulmonary diseases, organ dysfunction, systemic illnesses, and medication effects (1). The formation of PEs typically involves the accumulation of protein-rich fluid and cells within the pleural cavity. The pathophysiological features of PE differ based on the underlying condition.
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Nov 22, 2024 | 
insight.jci.org | JCI Insight |Jazib Uddin |Ankit Sharma |David Wu
AbstractSusceptibility to inflammatory bowel diseases (IBDs), Crohn’s disease (CD), and ulcerative colitis (UC) is linked with loss of intestinal epithelial barrier integrity and mitochondria dysfunction.
