Jason Turner

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A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease - Nature Immunology

Oct 22, 2024 | nature.com | Maria Kiourlappou |Lisa Gartner |Nicholas E. Ilott |Fadi Issa |Joanna Hester |Jason Turner | +12 more

AbstractPrecision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment response. We describe a therapeutic atlas for Crohn’s disease (CD) and ulcerative colitis (UC) following adalimumab, an anti-tumour necrosis factor (anti-TNF) treatment. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies (41 subjects), revealing disease-specific differences.

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