Jason Willis

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Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma - npj Precision Oncology

Feb 2, 2024 | nature.com | Abdelrahman MG Yousef |Mahmoud Yousef |Saikat Chowdhury |Mark Knafl |Brandon G. Smaglo |Jason Willis | +3 more

AbstractThe relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Overall survival (OS) analysis demonstrated that KRAS mutation status and subtypes were prognostic (p < 0.001).

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