Mark Knafl

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Molecular, Socioeconomic, and Clinical Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival

Sep 12, 2024 | jamanetwork.com | Mahmoud Yousef |Mohammad M. Fanaeian |Mark Knafl |Jennifer Peterson

Key PointsQuestion How do molecular, clinical, and socioeconomic covariables contribute to racial and ethnic disparities in colorectal cancer survival? Findings This single-center cohort study, including nearly 50 000 patients, found substantial racial disparity in overall survival and differing frequencies of driver gene variations.
Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma - npj Precision Oncology

Feb 2, 2024 | nature.com | Abdelrahman MG Yousef |Mahmoud Yousef |Saikat Chowdhury |Mark Knafl |Brandon G. Smaglo |Jason Willis | +3 more

AbstractThe relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Overall survival (OS) analysis demonstrated that KRAS mutation status and subtypes were prognostic (p < 0.001).

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