Jayachandran N. Kizhakkedathu

Mar 29, 2024 | nature.com | Serena MacMillan |Jayachandran N. Kizhakkedathu |Stephen Withers

AbstractABO blood group compatibility restrictions present the first barrier to donor-recipient matching in kidney transplantation. Here, we present the use of two enzymes, FpGalNAc deacetylase and FpGalactosaminidase, from the bacterium Flavonifractor plautii to enzymatically convert blood group A antigens from the renal vasculature of human kidneys to ‘universal’ O-type.

Aug 12, 2023 | nature.com | Tao Xu |Weifeng Zhao |Jayachandran N. Kizhakkedathu

AbstractClinical use of intraoperative auto-transfusion requires the removal of platelets and plasma proteins due to pump-based suction and water-soluble anticoagulant administration, which causes dilutional coagulopathy. Herein, we develop a carboxylated and sulfonated heparin-mimetic polymer-modified sponge with spontaneous blood adsorption and instantaneous anticoagulation.