Serena MacMillan

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Articles

Enzymatic conversion of human blood group A kidneys to universal blood group O - Nature Communications

Mar 29, 2024 | nature.com | Serena MacMillan |Jayachandran N. Kizhakkedathu |Stephen Withers

AbstractABO blood group compatibility restrictions present the first barrier to donor-recipient matching in kidney transplantation. Here, we present the use of two enzymes, FpGalNAc deacetylase and FpGalactosaminidase, from the bacterium Flavonifractor plautii to enzymatically convert blood group A antigens from the renal vasculature of human kidneys to ‘universal’ O-type.
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD-20 therapy

Oct 24, 2023 | biorxiv.org | Daniel Cooper |Serena MacMillan |Georg Meisl |Ashley Priddey

AbstractBackground: Patients with autoimmune/inflammatory conditions on anti-CD20 therapies, such as Rituximab, have suboptimal humoral responses to vaccination and are vulnerable to poorer clinical outcomes following SARS-CoV-2 infection. We aimed to examine how the fundamental parameters of antibody responses, namely affinity and concentration, shape the quality of humoral immunity after vaccination in these patients.

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