Jayaram Vijayakrishnan

Mar 25, 2024 | nature.com | Molly Went |Amit Sud |Charlie Mills |Philip J Law |Jayaram Vijayakrishnan |Ines Gockel | +5 more

AbstractFor many cancers there are only a few well-established risk factors. Here, we use summary data from genome-wide association studies (GWAS) in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to identify potentially causal relationships for over 3,000 traits. Our outcome datasets comprise 378,142 cases across breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian cancers, as well as 485,715 controls.