-
Oct 26, 2024 | 
nature.com | Máire Ní Leathlobhair |Anna Frangou |Ben Kinnersley |Alex J. Cornish |Eszter Lakatos |Andreas Gruber | +10 more
AbstractTesticular germ cell tumours (TGCT), which comprise seminoma and non-seminoma subtypes, are the most common cancers in young men. In this study, we present a comprehensive whole genome sequencing analysis of adult TGCTs. Leveraging samples from participants recruited via the UK National Health Service and data from the Genomics England 100,000 Genomes Project, our results provide an extended description of genomic elements underlying TGCT pathogenesis.
-
Aug 28, 2024 | 
interplasinsights.com | Philip J Law
BPF’s Philip Law invites the plastics industry to GRIPS 2024, a major industry conference to commemorate the legacy of former BPF president David Williams and explore innovations in sustainability.
Get to GRIPS on the 19th of September! This unique event on Global Innovation on Sustainable Plastics is to be held at The University of Sheffield and should be a priority date for all those who are serious about the sustainability of plastics.
-
Aug 7, 2024 | 
nature.com | Alex J. Cornish |Andreas Gruber |Ben Kinnersley |Anna Frangou |Giulio Caravagna |Boris Noyvert | +23 more
AbstractColorectal carcinoma (CRC) is a common cause of mortality1, but a comprehensive description of its genomic landscape is lacking2,3,4,5,6,7,8,9. Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer.
-
Aug 4, 2024 | 
nature.com | Molly Went |Gísli H. Halldórsson |Andrea Gunnell |Philip J Law |Amit Sud |Gudmar Thorleifsson | +24 more
AbstractMultiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel.
-
Jul 15, 2024 | 
nature.com | Jessica Hislop |Molly Went |Charlie Mills |Amit Sud |Philip J Law
Clonal haematopoiesis, the clonal expansion of a blood stem cell and its progeny, is increasingly detectable with age in the blood of healthy individuals [1, 2]. Clonal haematopoiesis of indeterminate potential (CHIP) is characterised by the expansion of clones with oncogenic mutations, primarily in DNMT3A, TET2, ASXL1, JAK2, and is associated with mosaic chromosomal alterations [2].
-
Jul 5, 2024 | 
interplasinsights.com | Philip J Law
BPF’s Philip Law discusses efforts to promote collaboration between the plastics industry and universities and foster innovation in sustainable plastics solutions.
One of the key dates in the BPF’s Annual General meeting is always in May. We were delighted to unanimously re-elect Nigel Flowers of Sumitomo Demag Plastics Machinery as president for a second year of office.
-
May 24, 2024 | 
interplasinsights.com | Philip J Law
Philip Law reflects on the record-breaking attendance of Chinaplas 2024 and underlines the importance establishing strong relationships with China in the plastics sector.
BPF has just returned from a great showing at Chinaplas which took place on 23-26 April 2024 in Shanghai, China. It attracted a record-breaking 321,879 visitors and thereby becoming the first plastics show to ever attract over 300,000 visitors.
-
Apr 9, 2024 | 
interplasinsights.com | Philip J Law
BPF’s Philip Law reflects on the federation’s rich heritage and pays tribute to former members who contributed to its industrial success.
Every so often, something happens to evoke nostalgia for the BPF heritage and the people who made the BPF what it is today. And so, it was three weeks ago that I heard of the passing of my former colleague from the late 1970s and 80s, Richard Edy (1945 – 2024), then head of public relations at the BPF.
-
Mar 25, 2024 | 
nature.com | Molly Went |Amit Sud |Charlie Mills |Philip J Law |Jayaram Vijayakrishnan |Ines Gockel | +5 more
AbstractFor many cancers there are only a few well-established risk factors. Here, we use summary data from genome-wide association studies (GWAS) in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to identify potentially causal relationships for over 3,000 traits. Our outcome datasets comprise 378,142 cases across breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian cancers, as well as 485,715 controls.
-
Mar 7, 2024 | 
interplasinsights.com | Philip J Law
BPF’s director-general Philip Law explains BPF’s productive start to 2024 after an insightful roundtable with the shadow minister for Business and Decarbonisation, Sarah Jones.
The BPF hit the ground running at the opening of 2024.
The highlight of January was a meeting with Sarah Jones MP, the shadow minister for Business and Decarbonisation. A small and representative group of BPF members, plus myself, met her for a discussion - a breakfast roundtable - on Wednesday, January 17th.
