Jean-Claude Béïque

Nov 5, 2024 | biorxiv.org | Michael Lynn |Len Maler |Jean-Claude Béïque

AbstractMonoaminergic nuclei such as the serotonergic dorsal raphe nucleus (DRN) receive synaptic inputs containing functionally distinct streams of information, yet the dimensionality of the resulting output population code and its cellular underpinning are currently unknown.

Sep 13, 2024 | biorxiv.org | Michael Lynn |Richard Naud |Jean-Claude Béïque |Len Maler

AbstractThe serotonergic dorsal raphe nucleus (DRN) receives diverse long-range synaptic inputs, yet the processing rules governing their contribution to DRN output spiking patterns are largely unknown. Here, we use electrophysiological, optogenetic and computational approaches to compare electrophysiological features of two major excitatory inputs onto DRN 5-HT neurons - the lateral habenula (LHb) and medial prefrontal cortex (mPFC).

Oct 2, 2023 | biorxiv.org | Xingyun Wang |Jean-Claude Béïque |Richard Naud

AbstractSynaptic plasticity is a core basis for learning and adaptation. Determining how synapses are altered by local signals, the learning rules, is the hinge about which brain activity pivots.