Jedrzej Wykretowicz

Nov 13, 2024 | nature.com | Jedrzej Wykretowicz |Nan Hu |Isabella A. Malek |Surinder Kumar |David Scott

Correction to: Leukemia https://doi.org/10.1038/s41375-024-02448-8, published online 25 October 2024In this article the affiliation details for Karan Bedi were incorrectly given as ‘Computational Biology, University of Michigan’ but should have been ‘Biostatistics, University of Michigan’. The original article has been corrected.

Oct 25, 2024 | nature.com | Nan Hu |Surinder Kumar |David Scott |Jedrzej Wykretowicz |Isabella A. Malek

AbstractWe performed gene expression profiling of mRNA/cDNA isolated from N = 117 flow sorted CLL. We detected aberrant expression of the metabolic enzyme branched chain amino acid transferase (BCAT1) in CLL with del17p/TP53mut. Through extensive validation, we confirmed the highly preferential expression of BCAT1 in CLL with del17p/TP53mut (66%) or trisomy 12 (77%). BCAT1 was not expressed in B cells isolated from normal human lymph nodes.