David Scott

Portland

Vice President and Head of News at Associated Press

VP & Head of News Strategy and Operations, @AP.

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Articles

Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection - Nature Communications

2 months ago | nature.com | Trever T. Greene |Carolina Chiale |Yu Fujita |Thekla Cordes |Christian M. Metallo |David Scott

AbstractType I Interferons (IFN-I) are central to host protection against viral infections, with plasmacytoid dendritic cells (pDC) being the most significant source, yet pDCs lose their IFN-I production capacity following an initial burst of IFN-I, resulting in susceptibility to secondary infections. The underlying mechanisms of these dynamics are not well understood. Here we find that viral infection reduces the capacity of pDCs to engage both oxidative and glycolytic metabolism.
Cell polarity proteins promote macropinocytosis in response to metabolic stress - Nature Communications

Dec 2, 2024 | nature.com | Aniruddha Deshpande |David Scott

AbstractMacropinocytosis has emerged as a scavenging pathway that cancer cells exploit to survive in a nutrient-deprived microenvironment. Tumor cells are especially reliant on glutamine for their survival, and in pancreatic ductal adenocarcinoma (PDAC) cells, glutamine deficiency can enhance the stimulation of macropinocytosis. Here, we identify the atypical protein kinase C (aPKC) enzymes, PKCζ and PKCι, as regulators of macropinocytosis.
Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia - Leukemia

Oct 25, 2024 | nature.com | Nan Hu |Surinder Kumar |David Scott |Jedrzej Wykretowicz |Isabella A. Malek

AbstractWe performed gene expression profiling of mRNA/cDNA isolated from N = 117 flow sorted CLL. We detected aberrant expression of the metabolic enzyme branched chain amino acid transferase (BCAT1) in CLL with del17p/TP53mut. Through extensive validation, we confirmed the highly preferential expression of BCAT1 in CLL with del17p/TP53mut (66%) or trisomy 12 (77%). BCAT1 was not expressed in B cells isolated from normal human lymph nodes.
Identifying interactions between TDP-43 N-terminal and RNA binding domains

Jul 31, 2024 | biorxiv.org | David Scott |Lipsa Jena |Samantha Perez-Miller |Vlad Kumirov

AbstractTAR DNA-binding Protein 43 (TDP-43) plays a crucial role in the pathophysiology and progression of Amyotrophic Lateral Sclerosis (ALS), affecting both familial and sporadic cases. TDP-43 is an intrinsically disordered multidomain protein that consists of an N-terminal domain (NTD1-102), two tandem RNA recognition motifs (RRM1102-177 and RRM2191-260), and an intrinsically disordered glycine-rich C-terminal261-414 domain.
High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma - Leukemia

Apr 4, 2024 | nature.com | David Reiss |Yumi Nakayama |Andrew P Weng |Christian Steidl |David Scott |C. Chris Huang

To the Editor:A hallmark of hematological malignancies such as diffuse large B-cell lymphoma (DLBCL) is heterogeneity, with contribution from the tumor and its microenvironment. Application of next generation sequencing technology to patient tumor biopsies revealed not only genetic and epigenetic underpinnings of tumor intrinsic heterogeneity [1, 2], but also the complexities of the tumor microenvironment (TME).
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment - Nature Communications

Apr 3, 2024 | nature.com | Jie Li |Christopher R Chin |Cem Meydan |Pedro Farinha |Yiyue Jiang |Martin Rivas | +9 more

AbstractDespite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces a more severe mouse lymphoma phenotype (vs either allele alone) and unexpectedly confers an immune evasive microenvironment manifesting as CD8+ T-cell exhaustion and reduced infiltration.
Denoising Non-Stationary Signals via Dynamic Multivariate Complex Wavelet Thresholding

Nov 16, 2023 | mdpi.com | Katherine B. Ensor |David Scott |Kim C. Raath |Alena Crivello

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma - Nature Cancer

Oct 9, 2023 | nature.com | David Scott |Hervé Tiriac

AbstractIn pancreatic ductal adenocarcinoma (PDAC), glutamine is a critical nutrient that drives a wide array of metabolic and biosynthetic processes that support tumor growth. Here, we elucidate how 6-diazo-5-oxo-l-norleucine (DON), a glutamine antagonist that broadly inhibits glutamine metabolism, blocks PDAC tumor growth and metastasis. We find that DON significantly reduces asparagine production by inhibiting asparagine synthetase (ASNS), and that the effects of DON are rescued by asparagine.
Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response - Nature Metabolism

Aug 7, 2023 | nature.com | Siwen Kang |Richard M. Higashi |David Scott |Zihai Li |Jun Yang |Andrew Lane | +1 more

AbstractRobust and effective T cell immune surveillance and cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth and cytokine production. Here, we show that asparagine (Asn) restriction on CD8+ T cells exerted opposing effects during activation (early phase) and differentiation (late phase) following T cell activation.
Pundits with egg on their face? It’s OK not to know…

Feb 1, 2023 | medium.com | David Scott

As a football fan I thoroughly enjoy the opinions pundits lay against my club. Martinez "too small", Casemiro "not world class", Ten Hag "no-one will remember him in 5 years". The likes of Souness, Murphy, Merson, O'Hara et al. don't have egg on their face, they've a full English Breakfast. Any ketchup with yours Graeme? It really is OK to say "I don't know", but seldom will they say it.

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David Scott @davidthornhill

8 May 23

RT @PulitzerPrizes: Congratulations to @AP, @mstyslav9, @EMaloletka, @VasilisaUKR and @lhinnant. #Pulitzer https://t.co/0CnT3UI1p0

David Scott @davidthornhill

8 May 23

RT @PulitzerPrizes: Congratulations to @AP. #Pulitzer https://t.co/yuyKy0NMkp

David Scott @davidthornhill

10 Mar 22

Freelance journalist Amir Aman Kiyaro, accredited with the @AP, has been unjustly jailed in Ethiopia for more than 100 days. @AP calls for his immediate release. #FreeAmirAmanKiyaro https://t.co/Nf19rHz5aU…

David Scott

Articles

Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection - Nature Communications

Cell polarity proteins promote macropinocytosis in response to metabolic stress - Nature Communications

Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia - Leukemia

Identifying interactions between TDP-43 N-terminal and RNA binding domains

High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma - Leukemia

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment - Nature Communications

Denoising Non-Stationary Signals via Dynamic Multivariate Complex Wavelet Thresholding

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma - Nature Cancer

Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response - Nature Metabolism

Pundits with egg on their face? It’s OK not to know…

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