Jeffrey E. Pessin

Sep 26, 2024 | biorxiv.org | Jiyeon Hwang |Junichi Okada |li Liu |Jeffrey E. Pessin

AbstractHepatic lipid metabolism is regulated by the autonomic nervous system of the liver, with the sympathetic innervation being extensively studied, while the parasympathetic efferent innervation is less understood despite its potential importance. In this study, we investigate the consequences of disrupted brain-liver communication on hepatic lipid metabolism in mice exposed to obesogenic conditions.

Jan 11, 2024 | biorxiv.org | Jiyeon Hwang |Junichi Okada |li Liu |Jeffrey E. Pessin

AbstractHepatic lipid metabolism is regulated by the autonomic nervous system of the liver, with the sympathetic innervation being extensively studied, while the parasympathetic efferent innervation is less understood despite its potential importance. In this study, we investigate the consequences of disrupted brain-liver communication on hepatic lipid metabolism in mice exposed to obesogenic conditions.

Nov 5, 2023 | biorxiv.org | Junichi Okada |li Liu |Jeffrey E. Pessin |Jiyeon Hwang

AbstractThe role of parasympathetic cholinergic innervation in hepatic lipid metabolism has been the subject of considerable debate because of a lack of neuroanatomical studies. We investigate the impact of the loss of function of parasympathetic cholinergic innervation to the liver on hepatic lipid metabolism in mice fed a high-fat diet (HFD).