Jiyeon Hwang

Dec 2, 2024 | biorxiv.org | Jiyeon Hwang |Junichi Okada |li Liu |Sangbhin Lee

AbstractThe visceral organ-brain axis, mediated by vagal sensory neurons, is essential for maintaining various physiological functions. Here, we investigate the impact of liver-projecting vagal sensory neurons on energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions.

Oct 22, 2024 | journals.plos.org | Jiyeon Hwang |Albert Einstein College |Junichi Okada |li Liu

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Hwang J, Okada J, Liu L, Pessin JE, Schwartz GJ, Jo Y-H (2024) The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet. PLoS Biol 22(10): e3002865.

Sep 26, 2024 | biorxiv.org | Jiyeon Hwang |Junichi Okada |li Liu |Jeffrey E. Pessin

AbstractHepatic lipid metabolism is regulated by the autonomic nervous system of the liver, with the sympathetic innervation being extensively studied, while the parasympathetic efferent innervation is less understood despite its potential importance. In this study, we investigate the consequences of disrupted brain-liver communication on hepatic lipid metabolism in mice exposed to obesogenic conditions.

Jan 11, 2024 | biorxiv.org | Jiyeon Hwang |Junichi Okada |li Liu |Jeffrey E. Pessin

AbstractHepatic lipid metabolism is regulated by the autonomic nervous system of the liver, with the sympathetic innervation being extensively studied, while the parasympathetic efferent innervation is less understood despite its potential importance. In this study, we investigate the consequences of disrupted brain-liver communication on hepatic lipid metabolism in mice exposed to obesogenic conditions.

Nov 5, 2023 | biorxiv.org | Junichi Okada |li Liu |Jeffrey E. Pessin |Jiyeon Hwang

AbstractThe role of parasympathetic cholinergic innervation in hepatic lipid metabolism has been the subject of considerable debate because of a lack of neuroanatomical studies. We investigate the impact of the loss of function of parasympathetic cholinergic innervation to the liver on hepatic lipid metabolism in mice fed a high-fat diet (HFD).