Jeffrey Okamoto

Mar 31, 2024 | biorxiv.org | Jeffrey Okamoto |Xianyong Yin |Joshua Chiou |Brady Ryan

AbstractWe present multi-integration of transcriptome-wide association studies and colocalization (Multi-INTACT), an algorithm that models multiple gene products (e.g. encoded RNA transcript and protein levels) to implicate causal genes and relevant gene products. In simulations, Multi-INTACT achieves higher power than existing methods, maintains calibrated false discovery rates, and detects the true causal gene product(s).