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Jul 15, 2024 | 
medrxiv.org | Ravi Mandla |Xianyong Yin |Ozvan Bocher |Kimberly Lorenz
J.B.M is an academic associate for Quest Diagnostics Inc. Endocrine R&D. MIMcC is now an employee of Genentech and a holder of Roche stock. A.H. is supported by the American Diabetes Association grant #11-23-PDF-35. O.B. has received funding from the European Unions Horizon 2020 research and innovation programme under Grant Agreement No 101017802 (OPTOMICS). A.P. is supported by the Wiener-Anspach Foundation, and the Fonds National de la Recherche Scientifique (FNRS).
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May 20, 2024 | 
digitalcommons.library.tmc.edu | Alice Williamson |Dougall M. Norris |Xianyong Yin |K Alaine Broadaway
Home > UTHealth > SPH > Journal Articles > 535 Journal Articles Humans, Insulin, Genome-Wide Association Study, Insulin Resistance, Diabetes Mellitus, Type 2, Glucose, Blood Glucose DOWNLOADS COinS...
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Mar 31, 2024 | 
biorxiv.org | Jeffrey Okamoto |Xianyong Yin |Joshua Chiou |Brady Ryan
AbstractWe present multi-integration of transcriptome-wide association studies and colocalization (Multi-INTACT), an algorithm that models multiple gene products (e.g. encoded RNA transcript and protein levels) to implicate causal genes and relevant gene products. In simulations, Multi-INTACT achieves higher power than existing methods, maintains calibrated false discovery rates, and detects the true causal gene product(s).
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Mar 6, 2024 | 
nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more
AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.
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Feb 19, 2024 | 
nature.com | Konstantinos Hatzikotoulas |Henry Taylor |Xianyong Yin |Kim Lorenz |Mark McCarthy |Anubha Mahajan | +6 more
AbstractType 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D.
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Jun 21, 2023 | 
frontiersin.org | Bioinformatics Laboratory |Eunice Lee |Xianyong Yin |Peer W. F
1Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Durham, NC, United States 2Genomics and Bioinformatics Laboratory, Seoul National University, Seoul, Republic of Korea 3National Institute of Environmental Health Sciences, Durham, NC, United States 4Genomic Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, United States 5Department of Obstetrics and Gynecology, University of...
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Jun 14, 2023 | 
jnnp.bmj.com | Xin Lin |Yuanhao Yang |Xianyong Yin |Valery Fuh-Ngwa
http://orcid.org/0000-0002-1563-8168Xin Lin1, Yuanhao Yang2,3, Valery Fuh-Ngwa1, Xianyong Yin4, http://orcid.org/0000-0001-6521-3056Steve Simpson-Yap1,5, http://orcid.org/0000-0001-9009-7472Ingrid van der Mei1, http://orcid.org/0000-0002-9429-4307Simon A Broadley6, Anne-Louise Ponsonby7,8, Ausimmune/ AusLong Investigators Group, Kathryn P Burdon1, Bruce V Taylor1, Yuan Zhou1 1 Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia 2 Mater Research...
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May 17, 2023 | 
frontiersin.org | Yao Lin |Minglei Yang |Xianyong Yin |Diptavo Dutta
Ce Zhong1, Chen Wu1, Yuan Lin2* and Dongxin Lin1* 1Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 2Beijing Advanced Innovation Center for Genomics (ICG), Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China Objectives: This study aimed to explore cell type level expression quantitative trait loci...
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Mar 28, 2023 | 
frontiersin.org | Cheeloo College |Xin Huang |Giacomina Brunetti |Xianyong Yin
1 IntroductionBlood pressure lowering through antihypertensive drugs is an established strategy for hypertension management to reduce the risk of developing cardiovascular diseases (1, 2). Hypertension and osteoporosis are often co-existed, especially in the aging population (3). The effects on osteoporosis from antihypertensive drugs can differ due to the diverse mechanisms of action among different classes of these drugs.
