Jennifer L Modesto

Nov 15, 2024 | biorxiv.org | Victoria Pearce |Seth G Kabonick |Kamalesh Verma |Jennifer L Modesto

AbstractHuman dietary choices control the gut microbiome. Industrialized populations consume abundant glucose and fructose, resulting in microbe-dependent intestinal disorders. Simple sugars inhibit the carbohydrate utilization regulator (Cur), a transcription factor in the prominent gut bacterial phylum, Bacteroidetes. Cur encodes products necessary for carbohydrate utilization, host immunomodulation, and intestinal colonization.