Jeroen Bisschop

Jul 10, 2024 | nature.com | Thomas Wälchli |Shigeki Takada |Hubert Rehrauer |Anuroopa Dinesh |Jeroen Bisschop |Fiona Farnhammer | +11 more

AbstractA broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood1.

Mar 20, 2023 | nature.com | Jeroen Bisschop |Peter Carmeliet |Katrien De Bock |Thomas Wälchli

AbstractThe CNS critically relies on the formation and proper function of its vasculature during development, adult homeostasis and disease. Angiogenesis — the formation of new blood vessels — is highly active during brain development, enters almost complete quiescence in the healthy adult brain and is reactivated in vascular-dependent brain pathologies such as brain vascular malformations and brain tumours.