Jessica Hislop

Oct 17, 2024 | nature.com | Molly Went |Jessica Hislop |Richard S. Houlston

Although acute myeloid leukaemia (AML) is one of the most common haematological malignancies in adults, its aetiological basis is poorly understood [1]. The only well recognised modifiable risk factors are smoking and exposure to benzene [2]. There is increasing evidence for the redox system playing a significant role in both the development and progression of AML [3].

Jul 15, 2024 | nature.com | Jessica Hislop |Molly Went |Charlie Mills |Amit Sud |Philip J Law

Clonal haematopoiesis, the clonal expansion of a blood stem cell and its progeny, is increasingly detectable with age in the blood of healthy individuals [1, 2]. Clonal haematopoiesis of indeterminate potential (CHIP) is characterised by the expansion of clones with oncogenic mutations, primarily in DNMT3A, TET2, ASXL1, JAK2, and is associated with mosaic chromosomal alterations [2].