Jessica Morris

Jan 10, 2025 | science.org | Daniel Rabe |Matthew Weller |Bhoktear Khan |Ahmed Gad |Jessica Morris |Lea Godret-Miertschin | +10 more

AbstractChimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse (CARIS) could explain differences in their tumor rejection kinetics.