Jiacheng Hu

Sep 4, 2024 | mdpi.com | Zhe Wang |Jiacheng Hu |Yushu Shi |Jinhui Cai

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Aug 28, 2023 | nature.com | Jiacheng Hu |Yu Sun

AbstractTranscription-activator-like effector (TALE)-based tools for base editing of nuclear and organellar DNA rely on double-stranded DNA deaminases, which edit substrate bases on both strands of DNA, reducing editing precision. Here, we present CyDENT base editing, a CRISPR-free, strand-selective, modular base editor.