Jialu Li

Oct 23, 2024 | nature.com | Jialu Li |Yaozong Li |Dong Deng

AbstractGlycosylphosphatidylinositol (GPI) acyltransferase is crucial for the synthesis of GPI-anchored proteins. Targeting the fungal glycosylphosphatidylinositol acyltransferase GWT1 by manogepix is a promising antifungal strategy. However, the inhibitory mechanism of manogepix remains unclear. Here, we present cryo-EM structures of yeast GWT1 bound to the substrate (palmitoyl-CoA) and inhibitor (manogepix) at 3.3 Å and 3.5 Å, respectively.

Jun 27, 2024 | nature.com | Pengliang Chi |Xiang Wang |Jialu Li |Yuqi Zhang |Lu Chen |Ruobing Ren | +2 more

Dear Editor, The proton-activated chloride (PAC) channel (also known as acid-sensitive outwardly rectifying anion channel, ASOR) plays critical roles in acid-induced cell death and endocytosis.1,2 The structural investigations revealed that three protomers construct one PAC channel.3,4,5 PAC’s three captured states (resting, activated, and desensitized) uncovered the gating and proton-sensing mechanism.3,4,5 However, little is known about the regulatory factors of PAC.6 This is a preview of...

Jan 3, 2024 | nature.com | Jialu Li |Pengliang Chi

AbstractThe subcortical maternal complex (SCMC) plays a crucial role in early embryonic development. Malfunction of SCMC leads to reproductive diseases in women. However, the molecular function and assembly basis for SCMC remain elusive. Here we reconstituted mouse SCMC and solved the structure at atomic resolution using single-particle cryo-electron microscopy. The core complex of SCMC was formed by MATER, TLE6 and FLOPED, and MATER embraced TLE6 and FLOPED via its NACHT and LRR domains.

Jul 17, 2023 | mdpi.com | Jialu Li |Xi Liu

Abstract:With the increasing demands on span length, aesthetics, and urban landscapes of pedestrian bridges, the fundamental frequency of pedestrian bridges is continuing to decrease, and their vibration and walking comfort issues are becoming increasingly prominent.