Ruobing Ren

Jun 27, 2024 | nature.com | Pengliang Chi |Xiang Wang |Jialu Li |Yuqi Zhang |Lu Chen |Ruobing Ren | +2 more

Dear Editor, The proton-activated chloride (PAC) channel (also known as acid-sensitive outwardly rectifying anion channel, ASOR) plays critical roles in acid-induced cell death and endocytosis.1,2 The structural investigations revealed that three protomers construct one PAC channel.3,4,5 PAC’s three captured states (resting, activated, and desensitized) uncovered the gating and proton-sensing mechanism.3,4,5 However, little is known about the regulatory factors of PAC.6 This is a preview of...

Nov 27, 2023 | nature.com | Ruobing Ren

Dear Editor,CXC chemokine receptor 3 (CXCR3) and three interferon-induced CXC chemokines, specifically CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC), are strongly associated with the migration of CD4+ Th1 cells and CD8+ cytotoxic T lymphocytes in immune responses1,2. The physiological and pathological functions of CXCR3 have been studied in infection, cancer, autoimmune diseases, and transplant rejection2,3,4,5.