Jian Xiao

Sep 1, 2024 | jitc.bmj.com | Jiawei Wang |Ao Xue |Jian Xiao

MethodsThe gastric cancer single-cell RNA sequencing (scRNA-seq) data sets used in this research were obtained from GSE206785, GSE167297, GSE150290, and GSE183904 which were from GEO database (https://www.ncbi.nlm.nih.gov/geo/), CRA002586 which was from the Genome Sequence Archive (https://ngdc.cncb.ac.cn/gsa/browse/CRA002586), and another scRNA data set was submitted by Anuja Sathe et al.

Apr 2, 2024 | genomemedicine.biomedcentral.com | Zegeng Chen |He Huang |Huangming Hong |Huageng Huang |Huawei Weng |Le Yu | +6 more

The clinical features of all 163 enrolled patients were examined and a side-by-side comparison among different cohorts was performed. Majority of patients (97.1%, 136 out of 140 patients whose treatment information is accessible) received first-line asparaginase-based chemotherapy. The NODE and ICGC cohorts are mostly comprised of primary patients, whereas the NKT_project and EGA cohorts contain more relapsed/refractory patients (Additional file 2: Table S2).

Oct 13, 2023 | nature.com | Jian Xiao |Weiping Zhang |Jie Luo

AbstractNiemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to endocytic recycling compartment (ERC). When ERC cholesterol level decreases, NPC1L1 interacts with LIMA1 and moves back to plasma membrane. However, how cholesterol leaves ERC is unknown.

May 29, 2023 | pubmed.ncbi.nlm.nih.gov | Jian Xiao |Jun Wu

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