Weiping Zhang

Jan 11, 2025 | nature.com | Yue Wu |Hao Zhang |Hualiang Jiang |Huiyong Yin |Weiping Zhang |Cheng Luo

AbstractReactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 and inhibits its peroxidase activity. Using three genetic models, we demonstrate that hepatic PRDX1 protects against NASH in male mice.

Aug 27, 2024 | bjui-journals.onlinelibrary.wiley.com | JiaYi Li |Weiping Zhang

Letter to the Editor Utilising the differential renal length index in paediatric pyeloplasty: clinical applications and considerations Jiayi Li,  Corresponding Author Jiayi Li Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China Correspondence: Jiayi Li, Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

Jun 11, 2024 | dialnet.unirioja.es | Xue Yu |Weiping Zhang |Yan Gao

Xue Yu[1];Weiping Zhang[2];Yan Gao[1][1]Traditional Chinese Medicine Hall, Cangzhou Central Hospital, Cangzhou, Hebei, China[2]Obstetrical Department II, Cangzhou Central Hospital, Cangzhou, Hebei, ChinaLocalización: Actas españolas de psiquiatría, ISSN 1139-9287, Vol. 52, Nº. 3, 2024, págs. 204-210Idioma: inglésEnlacesTexto completoResumenBackground: Postpartum depression (PPD) is a common mental disorder in postpartum women, negatively impacting physical and mental health.

Nov 21, 2023 | tandfonline.com | Jie Hu |Xiao Chen |Yu Chen |Weiping Zhang

AbstractMost empirical studies of complex networks return rich but noisy data, as they measure the network structure repeatedly but with substantial errors due to indirect measurements. In this article, we propose a novel framework, called the group-based binary mixture (GBM) modeling approach, to simultaneously conduct network reconstruction and community detection from such rich but noisy data.

Oct 13, 2023 | nature.com | Jian Xiao |Weiping Zhang |Jie Luo

AbstractNiemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to endocytic recycling compartment (ERC). When ERC cholesterol level decreases, NPC1L1 interacts with LIMA1 and moves back to plasma membrane. However, how cholesterol leaves ERC is unknown.