Jianfeng Liu

1 month ago | onlinelibrary.wiley.com | Yan Cui |Jianfeng Liu |Yu Song |Chen Chen

cGAMP cyclic GMP-AMP cGAS cyclic GMP-AMP synthase CLP cecal ligation and puncture CQ chloroquine DMSO dimethyl sulfoxide ELISA enzyme-linked immunosorbent assay H2 hydrogen HCH high concentration of H2 IFN type 1 interferon IRF3 interferon regulatory factor 3 MMP mitochondrial membrane potential MSS murine sepsis score mtDNA mitochondrial DNA MWM Morris water maze PINK1 PTEN-induced kinase 1 SAE sepsis-associated encephalopathy SAP spontaneous alternation performance SOD superoxide dismutase...

Oct 28, 2024 | cell.com | Zhiyong Zhang |Xia Li |Can Wang |Jianfeng Liu |X.Z. Shawn Xu |Fengfan Zhang

Sep 26, 2024 | nature.com | Chanjuan Xu |Chang Zhao |Wei Yan |Jianfeng Liu |Zhenhua Shao

AbstractDelta opioid receptor (δOR) plays a pivotal role in modulating human sensation and emotion. It is an attractive target for drug discovery since, unlike Mu opioid receptor, it is associated with low risk of drug dependence. Despite its potential applications, the pharmacological properties of δOR, including the mechanisms of activation by small-molecule agonists and the complex signaling pathways it engages, as well as their relation to the potential side effects, remain poorly understood.