Jianjun Chang

Feb 28, 2024 | biorxiv.org | Lisa D. Blackmer-Raynolds |Noah Schwartz |Jianjun Chang |MacKenzie L Bolen

AbstractEmerging evidence indicates that high-fat, high carbohydrate diet (HFHC) impacts central pathological features of Alzheimers disease (AD) across both human incidences and animal models. However, the mechanisms underlying this association are poorly understood. Here, we identify compartment-specific metabolic and inflammatory dysregulations that are induced by HFHC diet in the 5xFAD mouse model of AD pathology.