Lisa D. Blackmer-Raynolds

Jun 8, 2024 | biorxiv.org | Adam Hamilton |Lisa D. Blackmer-Raynolds |Yaqing Li |Sean Kelly

AbstractSpinal cord injury (SCI) results in a plethora of physiological dysfunctions across all body systems, including intestinal dysmotility and atrophy of the enteric nervous system (ENS). Typically, the ENS has capacity to recover from perturbation, so it is unclear why intestinal pathophysiologies persist after traumatic spinal injury.

Feb 28, 2024 | biorxiv.org | Lisa D. Blackmer-Raynolds |Noah Schwartz |Jianjun Chang |MacKenzie L Bolen

AbstractEmerging evidence indicates that high-fat, high carbohydrate diet (HFHC) impacts central pathological features of Alzheimers disease (AD) across both human incidences and animal models. However, the mechanisms underlying this association are poorly understood. Here, we identify compartment-specific metabolic and inflammatory dysregulations that are induced by HFHC diet in the 5xFAD mouse model of AD pathology.