Jiao Chen

Nov 27, 2023 | nature.com | Tao Tang |Yang Qiu |Jiao Chen

AbstractThe maternal-fetal interface shares similarities with tumor tissues in terms of the immune microenvironment. Normal pregnancy is maintained due to the immunosuppressed state, but pyroptosis induced by MITA can trigger the body’s immune response and disrupt the immunosuppressed state of the maternal-fetal interface, leading to abortion.

Nov 16, 2023 | dialnet.unirioja.es | Wei Li |Jinghui Yang |Xiang Xue |Jiao Chen

Sheng Ye[1];Wei Li[2];Jinghui Yang[3];Xiang Xue[3];Jiao Chen[3];Wei Zhao[3];Lei Jiang[4];Ling Jia[3][1]Department of Respiratory and Critical Care Medicine, Nanjing BenQ Medical Center, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. [2]Department of Critical Care Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.

May 31, 2023 | mdpi.com | Bowen Liu |Jun Liu |Yang Qiu |Jiao Chen

Abstract:MITA (also called STING), a master regulator of DNA-mediated innate immune activation, is a potential therapeutic target for viral infection and virus-related diseases. The circRNA-mediated ceRNA network plays important roles in gene regulation and may contribute to many human diseases. However, the relationship between MITA and recurrent miscarriage (RM) and its circRNA-related regulatory mechanisms remain unclear.