Jiawang Xiao

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Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish - Nature Communications

Nov 3, 2024 | nature.com | Yang Liu |Wei Qin |Jiawang Xiao |Gaurav K. Varshney |Ji-Feng Fei

AbstractCytosine base editing is a powerful tool for making precise single nucleotide changes in cells and model organisms like zebrafish, which are valuable for studying human diseases. However, current base editors struggle to edit cytosines in certain DNA contexts, particularly those with GC and CC pairs, limiting their use in modelling disease-related mutations.

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