Jihane Khalife

Jul 12, 2024 | science.org | Caterina Montani |Hui Ye |ZhiJun Qiu |Jihane Khalife |Purushoth Ethiraj |An-Ping Lin | +11 more

AbstractThe mechanism by which interferon regulatory factor 8 (IRF8) mutation contributes to lymphomagenesis is unknown. We modeled IRF8 variants in B cell lymphomas and found that they affected the expression of regulators of antigen presentation.

Jul 12, 2024 | science.org | Caterina Montani |Hui Ye |ZhiJun Qiu |Jihane Khalife

AbstractThe mechanism by which interferon regulatory factor 8 (IRF8) mutation contributes to lymphomagenesis is unknown. We modeled IRF8 variants in B cell lymphomas and found that they affected the expression of regulators of antigen presentation.

Oct 15, 2023 | biorxiv.org | ZhiJun Qiu |An-Ping Lin |Purushoth Ethiraj |Jihane Khalife

AbstractIn diffuse large B-cell lymphoma (DLBCL), the transcription factor IRF8 is the target of a series of potentially oncogenic events, including, chromosomal translocation, focal amplification, and super-enhancer perturbations. IRF8 is also frequently mutant in DLBCL, but how these variants contribute to lymphomagenesis is unknown. We modeled IRF8 mutations in DLBCL and found that they did not meaningfully impact cell fitness.