Caterina Montani

Jul 12, 2024 | science.org | Caterina Montani |Hui Ye |ZhiJun Qiu |Jihane Khalife |Purushoth Ethiraj |An-Ping Lin | +11 more

AbstractThe mechanism by which interferon regulatory factor 8 (IRF8) mutation contributes to lymphomagenesis is unknown. We modeled IRF8 variants in B cell lymphomas and found that they affected the expression of regulators of antigen presentation.

Jul 12, 2024 | science.org | Caterina Montani |Hui Ye |ZhiJun Qiu |Chaoqun Ma

AbstractAustralian mega-wildfires in the summer of 2019-2020 injected smoke into the stratosphere, causing strong ozone depletion in the lower stratosphere. Here, we model the smoke plume and reproduce its unexpected trajectory toward the middle stratosphere at ~35-kilometer altitude.

Jul 12, 2024 | science.org | Caterina Montani |Hui Ye |ZhiJun Qiu |Severin Ruoss |Chanond A. Nasamran |Scott Ball | +11 more

AbstractBone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the general population and elite athletes. Both tissues have been used interchangeably clinically even though their detailed composition, heterogeneity, and mechanisms of action have neither been rigorously inventoried nor compared.

Jul 12, 2024 | science.org | Caterina Montani |Hui Ye |ZhiJun Qiu |Xiaohua Yang

AbstractOxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize that 27HC binds to the estrogen receptor α (ERα) in the brain to regulate energy balance.

Jul 12, 2024 | science.org | Caterina Montani |Hui Ye |ZhiJun Qiu |Nick Love

AbstractMelanoma clinical outcomes emerge from incompletely understood genetic mechanisms operating within the tumor and its microenvironment. Here, we used single-cell RNA-based spatial molecular imaging (RNA-SMI) in patient-derived archival tumors to reveal clinically relevant markers of malignancy progression and prognosis.