Jinbo Yuan

Feb 21, 2023 | nature.com | Qiang Guo |Jinbo Yuan |Jiake Xu |Robert G. Parton |Hiroshi Takayanagi |Laila Abudulai | +1 more

AbstractOsteoclasts are giant bone-digesting cells that harbor specialized lysosome-related organelles termed secretory lysosomes (SLs). SLs store cathepsin K and serve as a membrane precursor to the ruffled border, the osteoclast’s ‘resorptive apparatus’. Yet, the molecular composition and spatiotemporal organization of SLs remains incompletely understood. Here, using organelle-resolution proteomics, we identify member a2 of the solute carrier 37 family (Slc37a2) as a SL sugar transporter.