Jinfu Zhang

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A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27

May 19, 2023 | onlinelibrary.wiley.com | Liangliang Xu |Sichuan Chengdu |Jinfu Zhang |Peng Wang

Abstract Background and Aims Accumulating circular RNAs (circRNAs) play important roles in tissue repair and organ regeneration. However, the biological effects of circRNAs on liver regeneration remain largely unknown. This study aims to systematically elucidate the functions and mechanisms of circRNAs derived from lipopolysaccharide-responsive beige-like anchor protein (LRBA) in regulating liver regeneration. Methods CircRNAs derived from mouse LRBA gene were identified using CircBase.

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