Jingtao Lilue

Oct 24, 2024 | biorxiv.org | David Adams |Michael A. Quail |Jingtao Lilue |Iraad Bonner

AbstractIt is over twenty years since the publication of the C57BL/6J mouse reference genome, which has been a key catalyst for understanding mammalian disease biology. However, the mouse reference genome still lacks telomeres and centromeres, contains 281 chromosomal sequence gaps, and only partially represents many biomedically relevant loci. We present the first T2T mouse genomes for two key inbred strains, C57BL/6J and CAST/EiJ.