Jingying Wu

Jun 11, 2024 | biorxiv.org | Jingying Wu |Yafei Wang |Xiaoyu Li |Yuanyuan Cai

AbstractMicroglia play critical roles in the brain physiology and pathology. CSF1R is primarily expressed in microglia. The mono-allelic CSF1R mutation causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a lethal neurological disease and no rational cure in clinical trials. There are no animal models mimicking human ALSP. In this study, we first developed mouse models based on human ALSP hotspot mutations.

Feb 24, 2023 | newsbreak.com | Jingying Wu

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Feb 24, 2023 | nature.com | Jingying Wu |Guili Lian

AbstractSarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number. TNF-α is also validated to play a prominent role in sarcopenia through its complex signaling pathways including cell death signaling.