Jinjing Chen

Sep 13, 2024 | pubs.acs.org | Wanting Zhang |Jinjing Chen |Yiming Chen |Chang Liu

Jul 2, 2024 | ift.onlinelibrary.wiley.com | Jinjing Chen |Wanting Zhang |Yiming Chen |Chang Liu

1 INTRODUCTION Soybean protein isolate (SPI) has been widely used due to its low cost and easy availability of materials. SPI is a complete protein of plant origin with the characteristics of high protein, low fat, calcium, and cholesterol (Liu et al., 2022). SPI can be equivalent to animal protein. It is one of the few plant proteins that can replace animal protein.

Jun 3, 2024 | digitalcommons.library.tmc.edu | Byron Kemper |Jinjing Chen |Ruoyu Wang |Feng Xiong

The nuclear receptor, farnesoid X receptor (FXR/NR1H4), is increasingly recognized as a promising drug target for metabolic diseases, including nonalcoholic steatohepatitis (NASH). Protein-coding genes regulated by FXR are well known, but whether FXR also acts through regulation of long non-coding RNAs (lncRNAs), which vastly outnumber protein-coding genes, remains unknown.

Apr 15, 2024 | elifesciences.org | Byron Kemper |Jinjing Chen |Ruoyu Wang |Feng Xiong

eLife assessment Using unbiased transcriptional profiling, the study reports a fundamental discovery of FincoR, a novel hepatic lncRNA generated from an enhancer element, which plays a role in FXR biology. The convincing findings have therapeutic implications in the treatment of MASH. The authors use state-of-the-art methodology and use unbiased transcriptomic profiling and epigenetic profiling, including validation in mouse models and human samples.