Jinwei Zhu

Sep 21, 2024 | mdpi.com | Xiaochen Fang |Jinwei Zhu

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Xiaochen Fang SciProfiles Scilit Preprints.org Google Scholar and Jinwei Zhu SciProfiles Scilit Preprints.org Google Scholar * School of Business, Jiangnan University, Wuxi 214122, China *Author to whom correspondence should be addressed.

Jul 24, 2024 | nature.com | Manja Idorn |Manutea C. Serrero |Xiaoyong Pan |Emil A. Thomsen |Ryo Narita |Muwan Chen | +7 more

AbstractThe brain is highly sensitive to damage caused by infection and inflammation1,2. Herpes simplex virus 1 (HSV-1) is a neurotropic virus and the cause of herpes simplex encephalitis3. It is unknown whether neuron-specific antiviral factors control virus replication to prevent infection and excessive inflammatory responses, hence protecting the brain. Here we identify TMEFF1 as an HSV-1 restriction factor using genome-wide CRISPR screening.