Joan Boyes

Aug 23, 2023 | biorxiv.org | Zeqian Gao |Miao Wang |Alastair Smith |Joan Boyes

AbstractEnhancers activate their cognate promoters over huge distances but how enhancer/promoter interactions become established is not completely understood. There is strong evidence that cohesin-mediated loop extrusion is involved but this does not appear to be a universal mechanism. Here, we identify an element within the mouse immunoglobulin lambda (Igλ) light chain locus, HSCλ1, that has characteristics of active regulatory elements but lacks intrinsic enhancer or promoter activity.