Jody M Mason

1 month ago | advanced.onlinelibrary.wiley.com | Andrew Brennan |Scott D. Lovell |Keith Vance |Jody M Mason

Graphical Abstract Covalent Peptide Library Screening Platform A peptide library screening platform was developed to discover covalent transcription factor inhibitors. It identified an antagonist cysteine residue which formed a inhibitory disulphide with cJun C269. Cysteine conversion to an electrophile generated an irreversible and selective cJun inhibitor, validating the approach for covalent antagonist discovery. More details can be found in article number 2416963 by Jody M.

2 months ago | biorxiv.org | Andrew Brennan |Jody M Mason

AbstractGenetically encoded peptide library screening is a powerful strategy for discovering inhibitors of protein-protein and protein-DNA interactions. The Transcription Block Survival (TBS) assay enables the in vivo selection of peptides that antagonise transcription factor (TF) binding by linking inhibition of DNA-binding to E.coli survival. However, previous TBS implementations required laborious re-engineering of the mDHFR coding region for each new target, limiting utility.

Oct 15, 2024 | waste360.com | Jody M Mason |Stefanie Valentic

“We extend our profound appreciation to Rickey for his steadfast dedication and exceptional leadership, which have“We extend our profound appreciation to Rickey for his steadfast dedication and exceptional leadership, which have“We extend our profound appreciation to Rickey for his steadfast dedication and exceptional leadership, which have“We extend our profo

Oct 15, 2024 | waste360.com | Jody M Mason |Stefanie Valentic

“We extend our profound appreciation to Rickey for his steadfast dedication and exceptional leadership, which have been instrumental in fostering our growth and success here at CWT,” “We extend our profound appreciation to Rickey for his steadfast dedication and exceptional leadership, which have been instrumental in fostering our growth and success here at CWT,”

Apr 15, 2024 | waste360.com | Jody M Mason |Stefanie Valentic

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