Scott D. Lovell

3 weeks ago | advanced.onlinelibrary.wiley.com | Andrew Brennan |Scott D. Lovell |Keith Vance |Jody M Mason

Graphical Abstract Covalent Peptide Library Screening Platform A peptide library screening platform was developed to discover covalent transcription factor inhibitors. It identified an antagonist cysteine residue which formed a inhibitory disulphide with cJun C269. Cysteine conversion to an electrophile generated an irreversible and selective cJun inhibitor, validating the approach for covalent antagonist discovery. More details can be found in article number 2416963 by Jody M.