Joe Harman

Aug 25, 2023 | nature.com | Nicholas Crump |Alastair Smith |Joe Harman |Nicole Jackson |Catherine Chahrour |Jaehoon Kim | +4 more

AbstractAberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly understood. Recent work suggests co-activators like BRD4 and Mediator have little impact on enhancer-promoter interactions.